Search results for "subcutaneous immunotherapy"

showing 4 items of 4 documents

Double-blind, randomized, placebo-controlled trial of allergen-specific immunotherapy with the major allergen Alt a1

2019

Background: There have been few studies conducted on the efficacy and safety of specific immunotherapy with allergen extracts of fungi compared with other allergen extracts, and there are no data on the major allergen Alt a 1 of the fungus Alternaria alternata. Objectives: We sought to evaluate the efficacy and safety of subcutaneous immunotherapy with 2 different doses of Alt a 1 in patients with rhinoconjunctivitis caused by sensitization to A alternata. Method: We performed a multicenter, randomized, double-blind, placebo-controlled trial with Alt a 1 administered subcutaneously in patients with allergic rhinoconjunctivitis with or without controlled asthma aged 12 to 65 years. Three gro…

AdultMalesafetyAllergymedicine.medical_specialtyAllergen immunotherapyAl·lèrgiaAdolescentImmunologyefficacyPlacebo-controlled studyPlacebomedicine.disease_causeFungal ProteinsYoung AdultAllergenDouble-Blind Methodchildrensubcutaneous immunotherapyInternal medicinemedicineadultsImmunology and AllergyHumansmolecular immunotherapyAdverse effectChildAgedConjunctivitis AllergicAllergen immunotherapyIntention-to-treat analysisbusiness.industryrhinoconjunctivitisclinical trialAllergensImmunoglobulin EMiddle Agedmedicine.diseaseAsthmaClinical trialfungal allergyDesensitization ImmunologicImmunoglobulin GAlt a 1Femalebusinesspurified allergen
researchProduct

Safety of sublingual immunotherapy started during the pollen season

2009

Sublingual immunotherapy (SLIT) is safer than subcutaneous immunotherapy (SCIT) and this has lead to the reconsideration of the use of ultra-rush schedules for SLIT. The aim of this study was to assess the safety of ultra-rush SLIT in pollen-allergic children according to different timing of administration in relation to the pollen season.In total, 34 children with pollen-induced rhinitis and 36 with pollen-induced asthma and rhinitis, were enrolled and assigned to three study groups: group 1 (n = 17 patients): conventional pre-seasonal-SLIT treatment; group 2 (n = 23 patients), seasonal SLIT ended before the pollen seasonal peak; group 3 (n = 30 patients), SLIT began after the pollen seaso…

Study groupsmedicine.medical_specialtyPediatricsAdolescentAdministration SublingualPollen Allergymedicine.disease_causePollenotorhinolaryngologic diseasesmedicineSubcutaneous immunotherapyHumansRhinitis Allergic Seasonal; Humans; Allergens; Asthma; Desensitization Immunologic; Child; Adolescent; Administration Sublingual; Pollen; Child PreschoolSublingual immunotherapyChildAsthmaPollen seasonbusiness.industryAllergenRhinitis Allergic Seasonalfood and beveragesGeneral MedicineAllergensmedicine.diseaseSlitAsthmaeye diseasesSurgerySLIT Ultra-RUSHDesensitization ImmunologicChild PreschoolPollensense organsbusinessHuman
researchProduct

Adherence issues related to sublingual immunotherapy as perceived by allergists.

2010

Silvia Scurati1, Franco Frati1, Gianni Passalacqua2, Paola Puccinelli1, Cecile Hilaire1, Cristoforo Incorvaia3, Italian Study Group on SLIT Compliance 1Scientific and Medical Department, Stallergenes, Milan, Italy; 2Allergy and Respiratory Diseases, Department of Internal Medicine, Genoa; 3Allergy/Pulmonary Rehabilitation, ICP Hospital, Milan, ItalyObjectives: Sublingual immunotherapy (SLIT) is a viable alternative to subcutaneous immunotherapy to treat allergic rhinitis and asthma, and is widely used in clinical practice in many European countries. The clinical efficacy of SLIT has been established in a number of clinical trials and meta-analyses. However, because SLIT is self-administered…

medicine.medical_specialtyPathologygenetic structuresefficacyAlternative medicineMedicine (miscellaneous)Adherence Cost Efficacy Side effects Sublingual immunotherapySettore MED/10 - Malattie Dell'Apparato Respiratoriosublingual immunotherapyALLERGENcostmedicineSubcutaneous immunotherapySublingual immunotherapyadherenceClinical efficacyIntensive care medicinePharmacology Toxicology and Pharmaceutics (miscellaneous)sublingual immunoterapyOriginal ResearchAsthmaAEROALLERGENSadherence; sublingual immunotherapy; efficacy; cost; side effectsbusiness.industryHealth Policymedicine.diseaseSliteye diseasesClinical trialside effectsPatient Preference and Adherenceadherence; sublingual immunoterapy; efficacy; cost; side effects.immunotherapysense organsAllergistsADHERENCE TO TREATMENTbusinessSocial Sciences (miscellaneous)
researchProduct

Efficacy of subcutaneous and sublingual immunotherapy with grass allergens for seasonal allergic rhinitis: a meta-analysis–based comparison

2012

Background: Subcutaneous (SCIT) and sublingual (SLIT) immunotherapy are the 2 most prescribed routes for administering allergen-specific immunotherapy. They were shown to be effective in control of symptoms and in reducing rescue medication use in patients with allergic diseases, but their effectiveness has to be balanced against side effects. In recent years, SLIT has been increasingly prescribed, instead of SCIT, because of improved safety and easy administration. Objective: We assessed which route is the most effective in the treatment of patients with seasonal allergic rhinitis to grass pollen. Methods: An indirect meta-analysis–based comparison between SCIT and SLIT was performed. Trea…

medicine.medical_specialtybusiness.industrymedicine.medical_treatmentImmunologySublingual immunotherapy subcutaneous immunotherapy allergic rhinitis grass meta-analysisPlaceboSlitlaw.inventionSettore MED/01 - Statistica MedicaRandomized controlled trialStrictly standardized mean differencelawMeta-analysisInternal medicineImmunologymedicineImmunology and AllergySublingual immunotherapybusinessAdverse effectDesensitization (medicine)
researchProduct